ABSTRACT
Objective To observe the effect of nitrous oxide (N2O) on the content of serum free hemoglobin ,and intercellular adhesion molecule‐1 (ICAM‐1) of patients with HIFU Therapy ,and investigate its action of tissue damage mechanism .Methods 50 patients with primary liver cancer undergoing HIFU surgery (ASA Ⅰ - Ⅱ class) were randomly divided into control group (group C) and experimental group(group N) ,25 patients of each group .General anesthesia method was used in both two groups , group C was by total intravenous anesthesia ,group N was adopted intravenous‐inhalation anesthesia .both two groups was adopted the same anesthesia induction method .anesthesia maintain of group N was joined N2 O on the basis of group C .both two groups were draw blood from the radial artery at the points of before anesthesia (T1 ) ,before operation (T2 ) ,1 h (T3 ) ,2 h (T4 ) ,3 h (T5 ) after intraoperative ,and 24 h after operation (T6 ) ,peroxidase reaction test and double antibody sandwich ELISA method were a‐dopted to detect the content of Fhb value and ICAM‐1 ;ultrasonography system of HIFU therapeutic instrument was used to meas‐ure the abdominal wall thickness of patients before and after operation .Results The content of FHb and ICAM‐1 in serum were significantly increased after operation than before with the anesthesia time (P<0 .05);compared with group C ,group N increased obviously at the same point in time (P<0 .05);preoperative and postoperative abdominal wall thickness value of group N was in‐creased significantly (P< 0 .05) .Conclusion It may be connected with N2 O enhanced ultrasound cavitation effect that the body produces more FHb and ICAM‐1 of group N in HIFU treatment ,and induces abdominal wall skin markedly swollen .
ABSTRACT
Objective To explore the concentration changing of human cartilage glycoprotein in elder hypertension patients with metabolic syndrome.Methods Thirty healthy people were served as control group.While 68 elder hypertension patients with metabolic syndrome were served hypertension group and they were divided into MS group and Non-MS group based on data of metabolic syndrome(MS) indicators.The serum YKL-40 concentration was measured by ELISA method,and the levels of hepatocyte growth factor(HGF),nitric oxide(NO),endothelin(ET) were also measured.Brachial artery flow mediated vasodilation(FMD) was used to assess endothelial function.Compared the difference of serum YKL-40 concentration of two groups and the relationship between YKL-40 and index of endothelial function.Results The concentration of serum YKL-40 in hypertension group was 51.8 (35.4,345.0) μg/L,higher than that of control group (33.4 (23.6,168.6)μg/L,Z =-3.156,P ＜ 0.01).The YKL-40 levels in control group,hypertemion group,Non-hypertension MS group,and hypertension MS group were 33.4 (23.6,168.6),51.8(35.4,345.0) μg/L,94.0(46.0,268.4),and 151.6(63.2,401.4) μg/L respectively,and the difference was significant.Serum YKL-40 concentration in hypertension group was higher than that of control group (Z =-3.156,P ＜ 0.01),while in hypertension MS group was higher than that of non-MS hypertension group(P =0.003).Of all study subjects,YKL-40 level was positively related to systolic blood pressure,diastolic blood pressure,body mass index,triglyceride (r =0.362,0.302,0.280,0.217,P ＜ 0.05) and was not corelate with FMD,ET,NO,HGF (P ＞ 0.05).Conclusion Serum YKL-40 concentration in patients with hypertension is related to blood pressure and not related to functional factors of vascular endothelium.